You want to silence all software and applications except an application: your music software, a video player like Spotify and mute the browser or other windows? With the Windows 10 volume mixer, it’s easy.
Right-click the volume icon on the taskbar. Click Open Volume Mixer.
Click the Cut Speakers button.
The sound of all applications is cut off. Click the Restore Volume button under the application you wish to hear only.
All applications are silent except the one you have activated.